Abstract:

The theory of Chemical Organisations is employed as a novel method to analyse and understand biological network models. The method allows to decompose a chemical reaction network into sub-networks that are closed and self-maintaining. Although only stoichiometry is considered to compute organisations, the analysis allows to narrow down the potential dynamic behaviour of the network: organisations represent potential steady state of the compositions of the system. We review the application to a model of sugar metabolism in e-coli and to an HIV dynamics model as well as a theoretical results on fragments of rule based models.